abstract：:A coordination complex cis-dichlorodiamminedihydroxoplatinum (IV) (oxoplatinum) was first synthesized in the USSR by Chugaev and Khlopin in 1927 [3]. Its marked antitumor properties were revealed by one of the authors of this article at the All-Union Cancer Research Center of the Academy of Medical Sciences of the USS...

journal_title：Neoplasma

authors： Presnov MA,Konovalova AL,Kozlov AM,Brovtsyn VK,Romanova LF

更新日期：1985-01-01 00:00:00

abstract：:The trends of age-adjusted incidence rates of malignant skin melanoma in Slovakia from 1968 to 1977 showed important increase with an annual increment of 5.8% in males and 3.2% in females. The mortality rates during this period remained lower and their increase was less expressed. The study of geographic patterns of i...

journal_title：Neoplasma

authors： Plesko I,Somogyi J,Dimitrova E,Havránková M,Kiss J

更新日期：1985-01-01 00:00:00

abstract：:A series of seven monoclonal antibodies recognizing cell surface antigens of similar distribution on a panel of leukemia/lymphoma and lymphoblastoid human cell lines was prepared by hybridoma technique after immunization with non-T, non-B acute lymphoblastic leukemia cell line REH. Immune reactivity of these monoclona...

journal_title：Neoplasma

authors： Poláková K,Chorváth B,Sedlák J,Duraj J,Matoska J,Karpatová M

更新日期：1985-01-01 00:00:00

abstract：:Immune complexes (IC) were examined in the sera of 100 patients with histologically confirmed non-Hodgkin's lymphoma (NHL) and 80 leukemic patients by the EA-rosette forming cell inhibition assay. Sera from 55 healthy controls were also tested for the presence of IC. Using 9% rosette inhibition as a base-line, IC were...

journal_title：Neoplasma

authors： Patel GV,Gopal R,Nadkarni JJ

更新日期：1984-01-01 00:00:00

abstract：:In a retrospective series of 45 patients with uterine cervix carcinoma Stage Ib and IIa who had been treated by radiation, biopsy material obtained prior to treatment was reevaluated for the presence of lymphocytic infiltration. The analysis based on 5 degrees of the intensity of stromal reaction has shown that the pr...

journal_title：Neoplasma

authors： Boljesíková E,Siracká E,Kubovcáková N,Gyarfásová M

更新日期：1984-01-01 00:00:00

abstract：:Institutional training of prescreening cytotechnicians started in 1972 in the Research Institute of Oncopathology, Budapest. Up to 1983 ten classes, i.e. 230 students have been trained. Authors acknowledge the good achievements of their students and state that the diagnostic reliability of the qualified cytotechnician...

journal_title：Neoplasma

authors： Arva P,Bodó M,Sugár J

更新日期：1984-01-01 00:00:00

abstract：:A group of 34 patients were treated by irradiation using 3 daily fractions of 1 Gy each at 4 h intervals. The overall TD in all of the patients was 60 Gy administered within 26 days. The irradiation was carried out by telecurietherapy utilizing 60Co. Twenty-eight patients had the tumor in the oropharynx, 1 in the hypo...

journal_title：Neoplasma

authors： Durkovský J,Jancina J,Siracká E,Krajci M

更新日期：1984-01-01 00:00:00

abstract：:Results obtained in 50 children with abdominal non-Hodgkin's lymphoma after a treatment program that comprised entire abdominal irradiation and chemotherapy are presented. Actuarial survival of the series at 3, 5 and 10 years is 65.8%, with 75.2% for patients in Stage II and 58.6% in Stage III. Patients in 5-9-year ag...

journal_title：Neoplasma

authors： Alert J,Longchong M,Castillo E,Valdés M,Jiménez J

更新日期：1984-01-01 00:00:00

abstract：:In this study there is presented a comparative analysis of immediate results after radiotherapy and combined treatment (radio- and chemotherapy) in 174 patients with highly differentiated inoperable lung cancer. The data were provided by participants of a joint investigation in some CMEA member countries (Hungary, USS...

journal_title：Neoplasma

authors： Kiseleva ES,Pitskhelauri VG,Trakhtenberg AK,Daryalova SL,Kasyanenko IV,Zakharchenkov AV,Lebedev VA,Zvekotkina LS,Glagolev AN,Bidyak IP

更新日期：1983-01-01 00:00:00

abstract：:The efficacy of cis-platinum in the treatment of recurrent advanced malignant melanoma is discussed and also the so far unpublished clinical data have been summed up. On account of the considerable differences among these data the clinical study of Stage II had been started which should contribute to the elucidation o...

journal_title：Neoplasma

authors： Mechl Z,Krejcí P

更新日期：1983-01-01 00:00:00

abstract：:Serological analysis of human membrane antigens have been performed using rabbit xenosera against membrane fraction obtained from different cells (B cell lines: RAJI, RAMOS, DAUDI, UHKT-2: T cell line: MOLT-3, as well as normal pooled lymphocytes). The direct cytotoxicity testing demonstrated that xenogeneic rabbit B ...

journal_title：Neoplasma

authors： Koubek K

更新日期：1983-01-01 00:00:00

abstract：:Induction of 6-thioguanine-resistant mutations was studied in Chinese hamster V79 cells treated with nitrofurylacrylic acid under aerobic and hypoxic conditions. The results obtained demonstrated that the mutagenic activity of this substance, less significant in aerobic conditions, was very high under hypoxic conditio...

journal_title：Neoplasma

authors： Slamenová D,Dusinská M,Gabelová A

更新日期：1983-01-01 00:00:00

abstract：:Presence of antibodies to the structural proteins of the feline leukemia virus and the feline oncornavirus-associated cell membrane antigen FOCMA was analyzed in sera of 120 cats from household environments. In our experiments 35% of the sera tested were positive with the viable cells of FL-74 feline lymphoma cell lin...

journal_title：Neoplasma

authors： Lizonová A,Grófová M

更新日期：1983-01-01 00:00:00

abstract：:DNA repair synthesis following dimethylnitrosamine (DMN) treatment in mouse liver was detected in vivo by means of histoautoradiography. This phenomenon was more significant around the acinus center (practically in all hepatocytes) than around the portobiliary space. Besides this also a decrease in semiconservative DN...

journal_title：Neoplasma

authors： Hochmann J

更新日期：1983-01-01 00:00:00

abstract：:Already a trace of oxygen mediates the one-electron transfer from 3,4-benzopyrene (benzo(a)pyrene, BP) to hydrogen peroxide or to tert. butyl hydroperoxide (ROOH), leading in this way to generation of highly reactive HO X, HO2 X or RO X and RO2 X radicals in nonpolar solvents at biological temperatures. At slightly hi...

journal_title：Neoplasma

authors： Tkác A,Bahna L

更新日期：1983-01-01 00:00:00

abstract：:The level of NCMC (natural cell-mediated cytotoxicity) in the spleen of Ehrlich ascites tumor-bearing mice at every 5 days after i. p. tumor transplantation, and the effect of cell-free ascitic fluid or serum of tumor bearers on natural cytotoxicity in vitro, were assessed. Spleen lymphocytes were used as effectors an...

journal_title：Neoplasma

authors： Olinescu A,Hristescu S,Mazilu E

更新日期：1983-01-01 00:00:00

abstract：:The associations of several clinical factors with general survival, percentage of relapse and survival in the group of patients who relapsed were analyzed in a series of 399 Stage II breast cancer patients operated and irradiated at the Institute of Oncology and Radiobiology in Havana. In another series of 187 patient...

journal_title：Neoplasma

authors： Lage A,Rodriguez M,Pascual MR,Diaz JW,Fernandez L

更新日期：1983-01-01 00:00:00

abstract：:During the decade 1968-1977 a total of 1488 cases of neoplasms were registered in Slovakia in children aged 0-14 years giving an average annual age-specific rate of 120.7 per million. Tumors prevailed in boys with 131.2 in comparison with girls showing 109.7 incidence rate/10(6). The most common malignancies were leuk...

journal_title：Neoplasma

authors： Plesko I,Somogyi J,Dimitrova E

更新日期：1983-01-01 00:00:00

abstract：:A patient with chronic myelocytic leukemia (CML) had a Philadelphia chromosome--Ph1(t(9q +; 22q--)) in all evaluated bone marrow cells at the time of diagnosis. After 29 months of intermittent therapy (chemotherapy and immunotherapy) and 2 months before clinical signs of blastic phase developed, three additional cell ...

journal_title：Neoplasma

authors： Izakovic V,Horák I,Krizan P

更新日期：1982-01-01 00:00:00

abstract：:Changes in distribution properties of T lymphocytes from lymphoid organs of normal rats 3H-uridine labeled in vitro and i. v. injected to tumor-bearing recipients were studied at different stages of tumor growth and rejection. Comparisons were made with T cell migration from normal donors to syngeneic recipients. A te...

journal_title：Neoplasma

authors： Klobusická M,Koníková E

更新日期：1982-01-01 00:00:00

abstract：:The kinetics of tumor growth and cell proliferation of eleven generations of spontaneous mammary carcinoma in F1(CBA2 X C57B1/6) mice was studied. Factors responsible for different sensitivity of tumors to 1-methyl-1-nitrosourea were analyzed. The process of tumor transplantation was accompanied by the reduction in la...

journal_title：Neoplasma

authors： Emanuel NM,Ostrovskaya LA,Krutova TV

更新日期：1982-01-01 00:00:00

abstract：:The effect of dibutyryl cyclic nucleotides, dbcAMP and dbcGMP, on the growth of BSC-1 cells has been studied in the presence and absence of kidney epithelial cell growth inhibitor. The growth response of the cells was dependent on concentrations of the dibutyryl cyclic nucleotides and on the presence or absence of ser...

journal_title：Neoplasma

authors： Fremuth F,Holley RW,Baldwin JH

更新日期：1982-01-01 00:00:00

abstract：:Regional lymph nodes in 80 cases of gastric and 70 cases of breast cancer have been examined and the reactive types have been correlated to the survival periods of the patients. In both groups of patients, a prognostically favorable sign was the detection of lymphocytic predominance combined with sinus histiocytosis, ...

journal_title：Neoplasma

authors： Riegrová D,Jansa P

更新日期：1982-01-01 00:00:00

abstract：:Projections for the incidence of all and selected major sites of cancer in the cities of Cracow and Bratislava were constructed for each year of the period 1978-1982 on the basis of data observed in the years 1968-1977. More or less increasing of unchanging trends were predicted for the malignant neoplasms of bladder,...

journal_title：Neoplasma

authors： Pawłega J,Plesko I,Dimitrova E

更新日期：1982-01-01 00:00:00

abstract：:Using the exocolonizing test, 59Fe-utilization technique and classical cytology, the authors observed 210 days after i.v. injection of 166.7 kBq of 239Pu/kg in about 30% of contaminated mice a proliferative activity in vertebral bone marrow, characterized with high relative numbers of pluripotent hemopoietic stem cell...

journal_title：Neoplasma

authors： Svoboda V,Kotasková Z

更新日期：1982-01-01 00:00:00

abstract：:The effect of a crude protein fraction from human urine having gonadotropin inhibitory activity (GGIM) was observed on the growth of 7,12-dimethylbenz(a)anthracene induced mammary tumors in Holtzman rat. Results show that while in 12 out 13 tumors, tumor growth was retarded/regressed following 2--4 weeks of CGIM treat...

journal_title：Neoplasma

authors： Sarkar S,Shah PN,Bagli NP

更新日期：1981-01-01 00:00:00

abstract：:Two simple spectrophotometric assays have been employed for the measurement of dopa oxidase activity and ceruloplasmin polyphenol oxidase activity in the sera from normal hamsters and hamsters bearing melanotic melanoma. Both activities were found to be augmented in tumor animals, the dopa oxidase activity much more p...

journal_title：Neoplasma

authors： Vachtenheim J,Pavel S,Duchon J

更新日期：1981-01-01 00:00:00

abstract：:Karyograms of the primary hepatomas induced in Wistar rats by aflatoxin b1 exhibited hypodiploid chromosome sets, and destruction of the chromosomes. Cytophotometric investigations showed a decrease of DNA content in the neoplastic cells, even to about 40% of DNA content in the normal hepatocytes in rats. In the neopl...

journal_title：Neoplasma

authors： Gasiorowski K,Zawirska B

更新日期：1981-01-01 00:00:00

abstract：:An in vitro system of colony forming cell inhibition was used for evaluation of 3-oxauracil (2,3-dihydro-1,3-6H-oxazine-2,6-dione) effectivity against bone marrow cells from 18 leukemic patients. The highest inhibitive activity of the 3-oxauracil was found in cases of acute lymphoblastic leukemia, comparing with bone ...

journal_title：Neoplasma

authors： Reiner P,Mardiak J,Reinerová M,Ujházy V

更新日期：1981-01-01 00:00:00

abstract：:Solid phase radioimmunoassay for detection of anti-BLV antibodies in sera of infected animals is described. Viral antigens bound to surface of polystyrene are able selectively adsorb the antibodies from serum. Detection of bound antibodies quantitatively was done by 125I-labeled protein A from Staphylococcus aureus. T...

journal_title：Neoplasma

authors： Zajac V,Altaner C

更新日期：1981-01-01 00:00:00

abstract：:The present communication is a comparative survey of the histological specimens derived from the dysplastic or neoplastic lesion of the uterine cervix of 400 women comprising two age-matched series (200 women in each) collected from two Finnish hospitals. Special emphasis was placed on the detection of the newly descr...

journal_title：Neoplasma

authors： Syrjänen KJ

更新日期：1981-01-01 00:00:00

abstract：:Serum levels of seven specific proteins mostly acute phase reactants (APR) have been studied (transferrin, alpha 2-macroglobulin, alpha 1-antitrypsin, haptoglobin, C3, ceruloplasmin, orosomucoid) in 14 healthy subjects and in 55 patients with multiple myeloma. The alpha 2-macroglobulin and transferrin are significantl...

journal_title：Neoplasma

authors： San Miguel J,Vicente V,Battle J,Hernandez F,Lopez Borrasca A

更新日期：1981-01-01 00:00:00

abstract：:The results of studies of a co-carcinogenic effect of two human infectious viruses in tissue culture are reported here. Viable vaccinia virus actively replicating in the cells of primary BALB/c tissue culture and in a number of continuous murine cell lines has been shown to induce in them expression of major structura...

journal_title：Neoplasma

authors： Mazurenko NP,Merekalova ZI,Pavlish OA,Bykovsky AF,Kurzman MJ,Mazurenko NN

更新日期：1981-01-01 00:00:00

abstract：:The neuroleptics, well known as stimulants of prolactin release, are supposed to increase breast cancer incidence. To verify this hypothesis, we selected a group of 853 deaths of female inpatients with mental diseases recorded in the Dr. G. Marinescu Hospital between 1929 and 1978. Using proportionally and indirect st...

journal_title：Neoplasma

authors： Costa D,Mesteş E,Coban A

更新日期：1981-01-01 00:00:00

abstract：:Inbred Wistar rats were fed aflatoxin B1 (AFB1) during a period of 15 weeks. Some of the rats were sacrificed successively at different time intervals, and the remaining animals died a natural death. Beginning with the day of AFB1 treatment termination multifocal hepatomas appeared on the 265th day in males and on the...

journal_title：Neoplasma

authors： Zawirska B,Bednarz W

更新日期：1981-01-01 00:00:00

abstract：:With the use of 14C-arginine it is shown that among the ascitic fluid proteins of Ehrlich tumor there appear basic proteins rich in arginine with the content of amino acid about 14%. The amount of these proteins is about 3%. They exhibit great similarity in respect to arginine content, electrophoretic mobility to the ...

journal_title：Neoplasma

authors： Farbiszewski R,Zdrodowska J,Kilczewska D

更新日期：1981-01-01 00:00:00

abstract：:The antineoplastic effect of 5-(2-dimethyl-aminoethoxy)-7-oxo-7H-benzo(c) fluorene, substance VUFB 13 468, was studied in leukemia L1210 and leukemia La. It was found that the test substance, in the form of base and in the form of hydrochloride, influenced favorably the survival of leukemic mice, in which the life spa...

journal_title：Neoplasma

authors： Pujman V,Cernochová S

更新日期：1981-01-01 00:00:00

abstract：:Sera from 51 melanoma patients and from 55 healthy donors were examined for the presence of immune complexes (ICs) by the EA-rosette forming cell inhibition assay. Using a cut-off point of 5% rosette inhibition, ICs were found in 144 out of 213 sera from patients with melanoma (67.6%) and in 11 out of 55 control subje...

journal_title：Neoplasma

authors： Sztaba-Kania M,Jassem J,Piskorzyńska M,Kondrat W

更新日期：1981-01-01 00:00:00

abstract：:Out of different nucleosides and deoxynucleosides testes for their ability to block the phosphorylation of labeled 5-aza-2'-deoxycytidine in the presence of ATP and the cell-free extract from mouse spleen only deoxycytidine and cytosine arabinoside depressed the reaction significantly. With the same system the phospha...

journal_title：Neoplasma

authors： Veselý J,Cihák A

更新日期：1980-01-01 00:00:00

abstract：:The experiments reported in this communication examined the immunological properties of cell lines cultured under (a) normal, physiological (Cont.Cal) and (b) experimental, non-physiological (Expt.Cal) conditions described in the preceeding paper. Determination of oncogenicity, humoral and cellular immunity of the cul...

journal_title：Neoplasma

authors： Hakim AA

更新日期：1980-01-01 00:00:00